Unlocking the potential of treatment adherence: Insights and opportunities

29th May, 2024

“The relationship between the patient and the healthcare provider must be a partnership to which both parties must contribute in order to make it work.” – Dr. Alberto Hidalgo, a genetics specialist at the National Rehabilitation Institute in Mexico City.

Chronic diseases, such as diabetes, hypertension and cancer, among others, represent a major burden for health systems. The epidemiological shift in disease burden from acute to chronic diseases over the past few decades has rendered acute care models of health service delivery inadequate to address the health needs of the population.

Poor adherence to chronic disease treatments is one of the key drivers of health system burden. Adherence to long-term therapy for chronic illnesses in developed countries averages 50 percent. In low- and middle-income countries, the rates are even lower. It’s no surprise that healthcare providers have spent years looking at ways to ensure that patients comply with the prescribed treatment.

The impact of non-adherence grows as the burden of chronic disease grows worldwide. Consequences of non-adherence to long-term therapies are poor health outcomes and increased healthcare costs. That’s because poor adherence to long-term therapies severely compromises the effectiveness of treatment. This is a critical issue both for a patient’s quality of life and for health economics.

What is adherence?

The World Health Organization (WHO) defines adherence as “the extent to which a person’s behavior—taking medication, following a diet and/or executing lifestyle changes—corresponds with agreed-upon recommendations from a health care provider.”

Earlier, it was considered that either the patients themselves, their health providers, or both were the source of this non-compliance. Nowadays, there’s a better understanding that the adherence process is dynamic and complex. That is why ensuring adherence to treatment goes far beyond just remembering to take your medication. The ability of patients to follow treatment plans in an optimal manner is often compromised by more than one barrier, including social and economic factors, the healthcare team and system, the characteristics of the disease, disease therapies and other patient-related factors. Addressing these barriers holistically is key to improving treatment adherence.

Simplistic approaches to improve adherence to treatment may no longer be the right approach. But what is? Let’s explore some of these solutions.

Partnership with patients

According to Dr. Alberto Hidalgo, a genetics specialist at the National Rehabilitation Institute in Mexico City, “the relationship between the patient and the healthcare provider must be a partnership to which both parties must contribute to make it work.”

In other words, the quality of the relationship between the provider and the patient is a key factor in maintaining adherence. “Patients should be active partners with health professionals in their own care, and good communication between the patient and the health professional is a must for an effective clinical practice”, added Dr. Hidalgo.

A personalized approach

Silvia Mendez, Country Operations Lead, Mexico at Axios International, has seen first-hand that effective adherence solutions must take into consideration the many dimensions of adherence.

“It starts with a strong relationship with the provider, but once they leave their doctors office, there are many other issues introduced,” said Silvia.

“Affordability is still one of the most significant challenges for patients in adhering to their prescribed treatment. However, there are other factors at play, such as unexpected expenses related to their disease or treatment, lack of understanding of their journey from the initial stages of diagnosis to reaching the benefit of their treatment, and even limited transportation options for appointments,” she says, adding “Furthermore, medical appointments often have long wait times, and there are gaps in the referral network. These factors not only hinder patient compliance to treatment but also put increased pressure on the healthcare system as non-compliance often breeds new complications in a patient’s health.”

That is why it is critical to look at the patient journey holistically and provide tailored, personalized adherence interventions for each patient because each is different.

Adopting an evidence-based approach, Axios International’s proprietary Patient Needs Assessment Tool (PNAT) customizes services to each patient, thereby increasing adherence, engagement, and program cost-efficiency​. The patient undergoes a personal needs assessment using PNAT to determine the support they need to stay on their prescribed treatment. By utilizing this validated scientific tool to assess and identify the unmet needs of the patient and understand the variations in adherence patterns and individual motivations, Axios is able to customize interventions to address the individual adherence needs of a patient, and in turn, maximize their medical benefit.

For instance, one patient may discontinue therapy due to intolerable side effects, the inconvenience of doctor visits, and apprehension about being reprimanded for non-adherence. Another patient with the same diagnosis may skip doses due to a demanding lifestyle, frequent travel, and a lack of comprehension regarding the severity of their condition. Recognizing these nuanced differences is pivotal in devising effective access strategies and solutions that cater to each patient’s needs. Based on the results of the PNAT assessment, patients enrolled in an Axios Supported Program have access to a personalized treatment support plan that addresses their therapy-related and social-related needs. Personalized care recognizes each individual’s unique circumstances, a key factor in achieving better health outcomes in long-term chronic disease management.

A multi-disciplinary approach to delivering personalized care

Adherence is a dynamic process and delivering personalized care requires a multi-disciplinary approach.

Healthcare providers should assess the patient’s readiness to adhere, provide advice on how to do it and follow up on the patient’s progress. However, healthcare providers often don’t have the time to address these individual challenges on their own, given their patient load and other responsibilities, especially in a pandemic situation where this was apparent. Access consulting and program partner Axios International can help complement their efforts by providing additional support to patients once they leave the facility, continuing to follow up with them even outside the hospital.

Social support received by patients from other members of their community is another important factor and has been consistently reported as an important driver of health outcomes and behaviors.

To overcome growing treatment adherence barriers, a stronger commitment to a multidisciplinary approach is needed. This will require coordinated action from healthcare professionals, policymakers, patient support groups, communities and patients themselves.

Adhering to treatment improves patient outcomes, leading to better health, reduced symptoms, and increased quality of life. Societally, it lowers healthcare costs, reduces disease spread, and enhances overall public health and productivity.

Navigating New Frontiers in Healthcare Compliance in 2024

29th May 2024

Healthcare organizations often face the dual challenge of safeguarding patient data while embracing innovations promising to enhance efficiency and effectiveness in healthcare delivery.

Axios International specializes in the design and implementation of sustainable access to healthcare solutions, with a particular focus in emerging markets and low- and middle-income countries. Our expertise in understanding the entire spectrum of the patient journey requires us to identify and mitigate a wide range of compliance issues.

For that reason, staying on top of new regulations and trends affecting the compliance space is a cornerstone of our business model and how we serve patients. Here, we explore the key trends shaping the compliance landscape and best practices for maintaining compliance in this rapidly evolving sector.

Technological Innovations and Compliance

AI and Compliance

No conversation about healthcare technology is complete today without mentioning the impact of artificial intelligence (AI). Morgan Stanley recently reported that the amount allocated to AI and machine learning (ML) by healthcare entities is anticipated to be 10.5 percent this year, more than double that of 2022. The bank contends that 94 percent of healthcare companies are using either AI and/or ML in some capacity. As a result, AI has the potential to directly influence healthcare compliance by helping to streamline key processes while enhancing data analytics capabilities.

The potential deployment of AI in compliance processes, however, introduces several complexities, particularly around data privacy and ethical considerations. The European Union’s new legislation on AI aims to ensure safety and adherence to fundamental rights, something that will influence benchmarks for global standards, yet this will still take time to be replicated in other key regions. The U.S. government has outlined its own requirements for AI systems to enhance privacy and prevent bias. The underlying message in these regulations is the importance of aligning AI deployment with existing legal frameworks to mitigate risks and enhance patient care outcomes.

Building a Reliable Compliance Program in the Age of AI

To ensure a strong compliance framework in a healthcare organization implementing AI, the Office of the Inspector General (OIG) in the U.S. Department of Health and Human Services suggests that the following elements should be present in an organization’s AI compliance strategy:

  • Implementing written policies
  • Designating a compliance officer and, if possible, a committee
  • Providing effective training
  • Establishing communication channels
  • Performing internal audits while enforcing disciplinary guidelines.

A healthcare organization will also need to establish a structured approach for departments wishing to implement AI that enables comprehensive risk management while meeting business needs. This involves identifying relevant internal and external stakeholders (including Board members with practical AI experience), selecting partners aligned with organizational values, and setting clear data governance standards.

Enhancing Data Security through Cybersecurity Measures

With the increasing adoption of digital health technologies like AI, cybersecurity is fast becoming a significant component of healthcare compliance. The increase in global cyberattacks has put a spotlight on healthcare, with it being a prime target due to the sensitive nature of its data. Last year, the World Economic Forum revealed that the healthcare industry alone reported data breaches which cost an average of $10.93 million per breach – almost twice that of the financial industry. To protect against attacks in an age of AI, it is imperative that healthcare organizations employ the latest cyber security protocols and parameters that are aligned with both their local government guidance and global standards.

At Axios, protecting patient data confidentiality is one of our most critical responsibilities. Ahmed El Hassan, Head of Quality, Compliance and Ethics at Axios International, says that patients have the right to control their personal data and make decisions about its use and disclosure.

“Axios fully respects patients’ autonomy by obtaining their informed consent for the collection, use, and sharing of their data and honoring their preferences regarding privacy settings and data sharing. From collection to data sharing, it is guided by the individual’s informed consent. Patient autonomy is pivotal in nurturing a trust-based relationship between healthcare providers and patients, a trust that is integral to the integrity of the healthcare system and the efficacy of the patient treatment journey,” says Ahmed.

By prioritizing informed consent and respecting patient preferences, Axios reinforces the trust that is foundational to the patient-provider relationship and crucial for a seamless and effective treatment journey.

Regulatory Changes and Compliance Requirements

Updates to HIPAA Regulations

The Health Insurance Portability and Accountability Act (HIPAA) regulations have undergone several recent updates aimed at enhancing patient rights and facilitating better access to personal health information (PHI). Key changes include reducing the response time for PHI requests and simplifying the process for patients to direct their PHI to third parties. The upcoming 2024 HIPAA revisions have clearly taken a hard line when it comes to patient data safety, with a focus on equipping patients with the ability to control their health data. Patients can now obtain copies of their records in electronic form and can ensure corrections and/or amendments to inaccurate information can be requested.

Ethical Compliance and Sustainability

Early last year, the EU introduced its Corporate Sustainability Reporting Directive (CSRD) and Corporate Sustainability Due Diligence Directive (CSDDD) which was a watershed moment in ethically responsible business practices in healthcare. These directives require healthcare organizations to assess and mitigate their impact on human rights and the environment. The resulting goal of greater transparency and accountability is meant to encourage new, more stringent compliance benchmarks that global healthcare providers must meet if they are to be seen as ready for the technological advancements that are at their doorstep.

Considerations Moving Forward

Healthcare organizations must put in place advanced compliance solutions to ensure their practices align with the evolving digital landscape and the latest standards and regulations. This can help safeguard their operations so they can continue to deliver safe and ethical healthcare services to the patients they serve. Looking ahead, the best performing, and most trusted healthcare organizations will be those that patients can rely on.